Midkine signaling maintains the self-renewal and tumorigenic capacity of glioma initiating cells

Conclusions: The MDK/ALK axis regulates the self-renewal capacity of GICs by controlling the autophagic degradation of the transcription factor SOX9. Inhibition of the MDK/ALK axis may be a therapeutic strategy to target GICs in GBM patients.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Israel L ó pez-Valero, David D á vila, Jos é Gonz á lez-Mart í nez, N é lida Salvador-Tormo, Mar Lorente, Cristina Saiz-Ladera, Sof í a Torres, Estibaliz Gabicagogeascoa, Sonia Hern á ndez-Tiedra, Elena Garc í a-Taboada, Marina Mendiburu-Eli ç Tags: Research Paper Source Type: research