HIF-1 α Promotes the Metastasis of Esophageal Squamous Cell Carcinoma by Targeting SP1

Conclusion: The results of our study indicate that HIF-1α promotes metastasis of ESCC by targeting SP1 in a hypoxic microenvironment. Further study on this mechanism may elucidate the possibility of HIF-1α and SP1 as new targets for the treatment of ESCC.

Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xueting Hu, Jiatong Lin, Ming Jiang, Xiaotian He, Kefeng Wang, Wenjian Wang, Chuwen Hu, Zhiwen Shen, Zhanghai He, Huayue Lin, Duoguang Wu, Minghui Wang Tags: Research Paper Source Type: research