Downregulation of SPARC Expression Decreases Cell Migration and Invasion Involving Epithelial-Mesenchymal Transition through the p-FAK/p-ERK Pathway in Esophageal Squamous Cell Carcinoma

Conclusions: These results demonstrated that downregulation of SPARC could decrease cell migration and invasion involving EMT via the p-FAK/p-ERK pathway that might serve as a novel therapeutic target against ESCC.

Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Fei Zhang, Yiyin Zhang, Jie Da, Zhenya Jia, Hongyang Wu, Kangsheng Gu Tags: Research Paper Source Type: research