Risk factors associated with antibiotic treatment failure of Buruli ulcer.

Conclusions:There is a low rate of treatment failure in Australian BU patients treated with rifampicin-based oral combination antibiotic therapy. Our study raises the possibility that treatment failure risk may be increased in males, body weight >90kg, immune suppression and in those taking rifampicin/clarithromycin antibiotic regimens but future pharmacokinetic and pharmacodynamics studies are required to determine the validity of these hypotheses. PMID: 32571813 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research