Investigating complement mediated interference in class I HLA-specific antibodies following renal transplantation.

DISCUSSION: Our data indicates that both EDTA and BSC are suitable assays in overcoming CMI. We recommend that all clinical laboratories adopt a validated assay designed specifically to abrogate CMI for all potential renal transplant recipients, as the standard assay is inhibited in nearly 20% of a post-transplant cohort.
PMID: 32574596 [PubMed - as supplied by publisher]

Source: Transplant Immunology - June 19, 2020 Category: Transplant Surgery Authors: Goldsmith P, Lowe D, Wong C, Howse M, Ridgway D, Hammad A, Mehra S, Christmas S, Gebel H, Bray R, Jones A Tags: Transpl Immunol Source Type: research