Association of micro RNA and Post-Operative Cognitive Dysfunction: A Review.

Association of micro RNA and Post-Operative Cognitive Dysfunction: A Review. Mini Rev Med Chem. 2020 Jun 21;: Authors: Yazit NAA, Juliana N, Das S, Teng NIMF, Effendy N, Azmani S, Kadiman S Abstract Postoperative Cognitive Dysfunction (POCD) refers to the condition of neurocognitive decline following a surgery in a cognitive and sensory manner. There are several risk factors, which may be life-threatening for this condition. Neuropsychological assessment of this condition is very important. In the present review, we discuss the association of apolipoprotein epsilon 4 (APOE ε4) and few miRNAs with POCD, and highlight the clinical importance for prognosis, diagnosis and treatment of POCD. Microarray is a genome analysis that can be used to determine DNA abnormalities. This current technique is rapid, efficient and high-throughout. Microarray techniques are widely used to diagnose diseases, particularly in genetic disorder, chromosomal abnormalities, mutations, infectious diseases and disease-relevant biomarkers. MicroRNAs (miRNAs) are a class of noncoding RNA that are widely found distributed in eukaryotes. Few miRNAs influence the nervous system development, and nerve damage repair. Microarray approach can be utilized to understand the miRNAs involved and its pathways in POCD development, unleashing its potential to be considered as a diagnostic marker for POCD. This paper summarizes and identifies the studies that use microarray bas...
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research