An acute rise of plasma sodium concentration associates with syndecan-1 shedding during hemodialysis.

An acute rise of plasma sodium concentration associates with syndecan-1 shedding during hemodialysis. Am J Physiol Renal Physiol. 2020 Jun 15;: Authors: Koch J, Idzerda NMA, Ettema EM, Kuipers H, Dam W, van den Born J, Franssen CF Abstract Endothelial dysfunction (ED) contributes to the high incidence of cardiovascular events in hemodialysis patients. Syndecan-1 in the endothelial glycocalyx can be shed into the circulation serving as a biomarker for ED. As sodium is a trigger for glycocalyx shedding, we now tested whether hemodialysis with higher dialysate sodium concentrations is associated with more syndecan-1 shedding compared with standard hemodialysis (SHD). In this cross-over study in 29 patients, plasma syndecan-1 was repeatedly measured during SHD and during Hemocontrol hemodialysis (HHD) which is characterized by initially higher dialysate and plasma sodium levels. Courses of syndecan-1 were compared with linear mixed models. Syndecan-1 shedding was assessed by area under the curve analysis. Plasma sodium increased early after the start of SHD and HHD, with higher values during HHD (30 minutes: 142.3 mmol/L versus 139.9 mmol/L; P<0.001). Syndecan-1 increased significantly during both conditions but the percentage change was higher (42.9% versus 19.5%) and occurred earlier (120min versus 180min during) during HHD. Syndecan-1 levels were significantly higher at 120 minutes during HHD compared to SHD (P<0.05). Overall sy...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research