Exploration of a novel prognostic risk signatures and immune checkpoint molecules in endometrial carcinoma microenvironment.
In this study, we devoted to investigate immune-related genes and tumor microenvironment (TME) in EC based on The Cancer Genome Atlas (TCGA) database. In total 799 up-regulated and 139 down-regulated immune-related and differentially expressed genes in EC were investigated for functional annotations and prognosis. By a conjoint Cox regression analysis, we built two risk models for OS and DFS, as well as the consistent nomograms. Immune-related pathways were revealed mostly enriched in the low-risk group. By further analyzing TME based on the risk signatures, the higher immune cell infiltration and activation, lower tumor purity and higher tumor mutational burden were found in low-risk group, which presented a better prognosis. Both the expression and immunophenoscore of immune checkpoints PD-1, CTLA4, PD-L1 and PD-L2 increased significantly in low-risk group. These findings may provide new ideas for novel biomarkers and immunotherapy targets in EC.
PMID: 32474122 [PubMed - as supplied by publisher]
Source: Genomics - Category: Genetics & Stem Cells Authors: Liu J, Nie S, Wu Z, Jiang Y, Wan Y, Li S, Meng H, Zhou S, Cheng W Tags: Genomics Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Databases & Libraries | Endometrial Cancer | Genetics | Immunotherapy | Men | Science | Study