Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration

Gastroesophageal reflux disease (GERD) is a risk factor for chronic lung allograft dysfunction. Bile acids —putative markers of gastric microaspiration—and inflammatory proteins in the bronchoalveolar lavage (BAL) have been associated with chronic lung allograft dysfunction, but their relationship with GERD remains unclear. Although GERD is thought to drive chronic microaspiration, the selection of p atients for anti-reflux surgery lacks precision. This multicenter study aimed to test the association of BAL bile acids with GERD, lung inflammation, allograft function, and anti-reflux surgery.

Source: The Journal of Heart and Lung Transplantation - May 18, 2020 Category: Transplant Surgery Authors: Chen Yang Kevin Zhang, Musawir Ahmed, Ella Huszti, Liran Levy, Sarah E. Hunter, Kristen M. Boonstra, Sajad Moshkelgosha, Andrew T. Sage, Sassan Azad, Ricardo Zamel, Rasheed Ghany, Jonathan C. Yeung, Oscar M. Crespin, Courtney Frankel, Marie Budev, Pali Sh Tags: ORIGINAL CLINICAL SCIENCE Source Type: research