Outcome of patients with severe AL amyloidosis and biopsy-proven renal involvement ineligible for bone marrow transplantation.

CONCLUSIONS: To the best of our knowledge this is the first case series in which the whole cohort of patients with urinary or functional abnormalities underwent a histological evaluation. None of the patients were eligible for bone marrow transplantation. Hematologic response was 57.1%, while renal response was much lower (35%). Of note, the Staging System did not completely apply to this peculiar setting of patients in whom renal involvement was not presumptive but biopsy-proven. More aggressive approaches may be needed in these patients to avoid the inexorable progression of the disease. PMID: 32472525 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32472525?dopt=Abstract

Source: Journal of Nephrology - May 28, 2020 Category: Urology & Nephrology Authors: Fenoglio R, Baldovino S, Ferro M, Sciascia S, Rabajoli G, Quattrocchio G, Beltrame G, Naretto C, Rossi D, Alpa M, Barreca A, Papotti MG, Roccatello D Tags: J Nephrol Source Type: research