Identifying modifier genes for hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) severity greatly varies among patients even with the same HCM gene mutations. This variation is largely regulated by modifier gene(s), which, however, remain largely unknown. The current study is aimed to identify modifier genes using BXD strains, a large murine genetic reference population (GRP) derived from crosses between C57BL/6  J (B6) and D2 DBA/2 J (D2) mice. D2 mice is a natural model that carry the genetic basis and phenotypes of HCM.

Source: Journal of Molecular and Cellular Cardiology - May 24, 2020 Category: Cytology Authors: Yuanjian Chen, Fuyi Xu, Undral Munkhsaikhan, Charlie Boyle, Theresa Borcky, Wenyuan Zhao, Enkhsaikhan Purevjav, Jeffrey A. Towbin, Fang Liao, Robert W. Williams, Syamal K. Bhattacharya, Lu Lu, Yao Sun Source Type: research