Neuroprotective efficiency of tetanus toxin c fragment in model of global cerebral ischemia in mongolian gerbils.

In this study, the TTC effect was tested for the first time in animal model of global cerebral ischemia induced by 10-min occlusion of both common carotid arteries. The aim was to evaluate the effect of TTC gene therapy treatment on the development and expression of global cerebral ischemia/reperfusion-induced oxidative stress and motor hyperactivity in Mongolian gerbils. Several oxidative stress and motor behavioral parameters were investigated between 2h and 14 d after reperfusion. Neuroprotective efficiency of TTC was observed in the forebrain cortex, striatum, hippocampus, and cerebellum at the level of each examined oxidative stress parameter (nitric oxide level, superoxide production, superoxide dismutase activity, and index of lipid peroxidation). Additionally, TTC significantly decreased ischemia-induced motor hyperactivity based on tested parameters (locomotion, stereotypy, and rotations). As judged by biochemical as well as behavioral data, treatment with TTC for the first time showed neuroprotective efficiency by reduction of ischemia-induced oxidative stress and motor hyperactivity and can be a promising strategy for ischemia-induced neuronal damage treatment. PMID: 24365489 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research

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Publication date: Available online 17 July 2019Source: Journal of Clinical NeuroscienceAuthor(s): Zeynep Selen Karalok, Zeynep Öztürk, Altan GunesAbstractThe aim of this study is to evaluate the abnormal cortical structures associated with newly diagnosed benign epilepsy with centrotemporal spikes (BECTS) patients and assessed the effects of comorbid attention-deficit/hyperactivity (ADHD) on these abnormalities. Newly diagnosed BECTS patients (n = 33, 23 males) and age-matched healthy controls (n = 48) were evaluated by surface and volumetric MRI. CAT12 toolbox (HYPERLINK “http://www.neuro.uni-jena....
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
THURSDAY, July 18, 2019 -- Athletes with attention-deficit/hyperactivity disorder (ADHD) with concussion seem to have longer recovery than controls, regardless of their psychostimulant medication status, according to a study presented at the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
In conclusion, PEI-CeO2 nanocarriers could act as a potential candidate for gene and drug delivery to cancerous and tumor cells.Graphical abstract
Source: Life Sciences - Category: Biology Source Type: research
A 2-year-old male pediatric patient experienced a partial occlusion of the internal carotid and subsequent asphyxiation resulting in hypoxic brain injury that was later misdiagnosed as primary attention deficient hyperactivity disorder (ADHD). Imaging anal...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Authors: Tran K, Wu J Abstract A 2-year-old male pediatric patient experienced a partial occlusion of the internal carotid and subsequent asphyxiation resulting in hypoxic brain injury that was later misdiagnosed as primary attention deficient hyperactivity disorder (ADHD). Imaging analyses using diffusion tensor imaging (DTI), positron emission tomography (PET), and magnetic resonance imaging (MRI) quantitative volumetrics (QV) were used nine years following the incident to identify whether his development of ADHD is of a primary heritability or secondary hypoxic brain injury sequelae. The patient's DTI analysis g...
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
In conclusion, vitamin D status among pregnant Mongolians is severely depressed throughout the year and should be addressed through fortification and supplementation, while in the U.S.), deficiency is associated with specific characteristics targetable through supplementation.
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Abstract Tetanus (TeNT) and botulinum (BoNT) neurotoxins, the causative agents of tetanus and botulism, respectively, are the most potent toxic molecules known to mankind. This extreme potency is attributed to: i) their specificity for essential components of the neurotransmitter release machinery present at vertebrate synapses, and ii) their high-affinity targeting to motor neurons by binding to polysialogangliosides and protein receptors. Comprising the clostridial neurotoxin family, TeNT and BoNTs engage distinct surface receptors and intracellular sorting pathways in neurons. BoNTs bind to the intraluminal dom...
Source: Toxicon - Category: Toxicology Authors: Tags: Toxicon Source Type: research
Conclusion While government groups maintain that no studies have been done to compare the health of vaccinated to unvaccinated, the reality is that several comparative studies have been completed by independent researchers in the US and in other countries. The Centers for Disease Control and Prevention refuses to conduct such studies, claiming they would be unethical to perform. In reality, these studies could easily be performed, since many educated parents choose to not vaccinate their children. The evidence is overwhelming. Studies completed in New Zealand, Germany, Africa, Great Britain and the United States have come ...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Top Picks Top Stories truth about vaccines vaccinated vs. unvaccinated Source Type: blogs
Conclusion While government groups maintain that no studies have been done to compare the health of vaccinated to unvaccinated, the reality is that several comparative studies have been completed by independent researchers in the US and in other countries. The Centers for Disease Control and Prevention refuses to conduct such studies, claiming they would be unethical to perform. In reality, these studies could easily be performed, since many educated parents choose to not vaccinate their children. The evidence is overwhelming. Studies completed in New Zealand, Germany, Africa, Great Britain and the United States have come ...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Top Picks Top Stories truth about vaccines vaccinated vs. unvaccinated Source Type: blogs
This article is part of a Special Issue entitled: Pore-Forming Toxins edited by Mauro Dalla Serra and Franco Gambale.
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
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