GSE150134 Voltage-gated Sodium Channel SCN5A Promotes Tumor Progression and Enhances Chemosensitivity to 5-Fluorouracil in Colorectal Cancer

Contributors : Qiaoqi Sui ; Jianhong Peng ; Kai Han ; Junzhong Lin ; Rongxin Zhang ; Qingjian Ou ; Yuxiang Deng ; Wenhao Zhou ; Lingheng Kong ; Jinghua Tang ; Binyi Xiao ; Yuan Li ; Long Yu ; Yujing Fang ; Peirong Ding ; Zhizhong PanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSCN5A was reported to promote proliferation and invasiveness potential in colorectal cancer, yet the mechanism was not clarified, and little was known about its association with chemosensitivity to 5-fluorouracil. In the current study, elevated SCN5A expression were associated with poor prognosis and metastasis in colorectal cancers, whereas stage II-III patients with up-regulated SCN5A expression were more likely to benefit from 5-fluorouracil-based adjuvant chemotherapy. SCN5A could promote proliferation and invasiveness potential through regulating cell cycle and epithelial-mesenchymal transition in colorectal cancer cells. Furthermore, SCN5A regulated Ras signaling by stabilizing KRas-calmodulin complex through Ca2+ influx. Apart from that, under 5-fluorouracil treatment, SCN5A promoted calmodulin-dependent apoptosis in colorectal cancers.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research