BCS Class II drug loaded protein nanoparticles with enhanced oral bioavailability: in vitro evaluation and in vivo pharmacokinetic study in rats.

BCS Class II drug loaded protein nanoparticles with enhanced oral bioavailability: in vitro evaluation and in vivo pharmacokinetic study in rats. Drug Dev Ind Pharm. 2020 May 02;:1-19 Authors: Kasekar NM, Singh S, Jadhav KR, Kadam VJ Abstract The aim of the study was to improve the bioavailability of atorvastatin calcium (ATC) by formulating polymeric nanoparticles with an easy and cost-effective approach. ATC entrapped gelatin nanoparticles (AEGNPs) were prepared by using a simple one-step desolvation method. The formed nanoparticles were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry. Morphological study exhibited a homogenous spherical shape of formulated nanoparticles. FTIR studies revealed the chemical compatibility of the drug with gelatin. The improvement in drug delivery kinetics of AEGNPs could be attributed to amorphization along with the reduction in particle size of ATC. The pharmacokinetic study in Sprague Dawley rats revealed that the Cmax and AUC0-24 of AEGNPs in rats were ∼4 fold and ∼11 fold higher than that of pure atorvastatin calcium suspension. The research presented successfully shows that AEGNPs preparation by one step desolvation, using minimum excipients is a quick, easy and reproducible method. These results suggest that the ATC encapsulated gelatin nanoparticles is a promising approach for the oral delivery of ATC, improving t...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research