Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke

Conclusion
These results, therefore, show ANGPTL4 counteracts the loss of vascular integrity in ischaemic stroke, by restricting Src kinase signalling downstream from VEGFR2. ANGPTL4 treatment thus reduces oedema, infarct size, neuronal loss, and improves mice behaviour. These results suggest that ANGPTL4 constitutes a relevant target for vasculoprotection and cerebral protection during stroke.

Source: European Heart Journal - December 14, 2013 Category: Cardiology Authors: Bouleti, C., Mathivet, T., Coqueran, B., Serfaty, J.-M., Lesage, M., Berland, E., Ardidie-Robouant, C., Kauffenstein, G., Henrion, D., Lapergue, B., Mazighi, M., Duyckaerts, C., Thurston, G., Valenzuela, D. M., Murphy, A. J., Yancopoulos, G. D., Monnot, C Tags: BASIC SCIENCE Source Type: research