Comparison of effects of L/N-type and L-type calcium channel blockers on post-infarct cardiac remodeling in spontaneously hypertensive rats.

Comparison of effects of L/N-type and L-type calcium channel blockers on post-infarct cardiac remodeling in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 2020 Apr 23;: Authors: Naseratun N, Kobara M, Watanabe Y, Toba H, Nakata T Abstract Hypertension and coronary events are becoming more prevalent in aging societies, and myocardial infarction usually occurs in calcium channel blocker (CCB)-treated hypertensive patients. We herein compared the effects of cilnidipine, an L/N-type CCB and amlodipine, an L-type CCB, on post-infarct left ventricular (LV) remodeling in spontaneously hypertensive rats (SHRs). Male SHRs were subjected to 30 minutes of left coronary artery occlusion followed by reperfusion (MI group). The administration of cilnidipine (10 mg/kg/day; MI+Cil group) or amlodipine (10 mg/kg/day; MI+Aml group) was initiated one week before surgery and continued for five weeks. Both CCBs decreased blood pressure. Four weeks after surgery, cilnidipine, but not amlodipine, attenuated LV dilatation, fractional shortening impairments, end-diastolic pressure elevations, and tau elongation. In the non-infarct region, myocyte hypertrophy and brain natriuretic peptide (BNP) mRNA levels were similarly attenuated by both CCBs. On the other hand, interstitial fibrosis, the mRNA expression of collagen type III and TGF β and immunohistological TGF β protein expression in the non-infarct region were reduced more in the MI+Cil gr...
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research