The Effect of Granisetron on Sensory Detection and Pain Thresholds in Facial Skin of Healthy Young Males

Background: The specific serotonin type 3 (5-HT3)-receptor antagonist granisetron effectively reduces clinical as well as experimental muscle pain and hyperalgesia and with a duration that exceeds that of lidocaine. Hence, it may be an alternative to lidocaine as a local anesthetic. There are also some indications that granisetron in addition to 5-HT3 receptors blocks sodium channels. Thus, the local anesthetic effect by granisetron may resemble that of lidocaine, but this has not been tested. The aim of this study was therefore to compare the effect granisetron has on facial skin sensitivity to the effect of lidocaine and isotonic saline.Methods: This was a randomized, controlled, and double-blind study, in which 1 ml of either granisetron (test-substance), lidocaine (positive control), or isotonic saline (negative control) was injected into the skin over the masseter muscle at three different occasions in 18 healthy males (27.2 ± 5.8 years old). Skin detection thresholds and pain thresholds for thermal stimuli as well as mechanical detection thresholds and sensitivity to a painful mechanical (pinprick) stimulus were assessed before (baseline) and 5, 20, 40, and 60 min after injection. The quality and area of subjective sensory change over the cheek were assessed 20 min after injection.Results: All substances increased the mechanical detection threshold (granisetron: p = 0.011; lidocaine: p = 0.016; saline: p = 0.031). Both granisetron and lidocaine, but not isotonic ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

Related Links:

ConclusionsThis trial does not support the use of dexamethasone prior to intrathecal morphine for PONV prophylaxis in Cesarean delivery.Trial registrationwww.clinicaltrials.gov (NCT01734161); registered 27 November, 2012.
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
Conclusions: Occlusion of these catheters occurs at a very high rate, and the catheter embolus might be composed of clotted blood, plasma, and/or fibrin.
Source: Saudi Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
Conclusion: Pain decreased the second day after cardiac surgery compared to day 1. Paracetamol was the most prescribed analgesic; however, there was an underutilization which might be affected by insufficient pain reporting. Future improvement could focus on multimodal pain management and proper communication of pain experience.
Source: Saudi Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
Continuous epidural analgesia (CEA) using local anesthetics is frequently used to control herpes zoster pain and prevent postherpetic neuralgia (PHN). However, few studies have been conducted to determine the efficacy of epidural drugs administered as CEA to manage PHN. This retrospective study was designed to evaluate the effectiveness of CEA with ropivacaine alone or with ropivacaine and fentanyl for controlling pain caused by PHN. We reviewed the medical records of 71 patients. We studied 2 groups: epidural ropivacaine (ER; CEA with ropivacaine alone; n = 44) and epidural ropivacaine and fentanyl (Epidural ropivaca...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
(University of Colorado Anschutz Medical Campus) Researchers at the University of Colorado College of Nursing and the School of Medicine Department of Anesthesiology at the Anschutz Medical Campus found that the use of nitrous oxide (N2O) as a pain relief option for individuals in labor is safe for newborn children and laboring individual, and converting to a different form of pain relief such as an epidural or opioid is influenced by a woman's prior birth history and other factors.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
te;n Cecili Macián-Romero Of the five nerves that innervate the foot, the one in which anesthetic blocking presents the greatest difficulty is the tibial nerve. The aim of this clinical trial was to establish a protocol for two tibial nerve block anesthetic techniques to later compare the anesthetic efficiency of retromalleolar blocking and supramalleolar blocking in order to ascertain whether the supramalleolar approach achieved a higher effective blocking rate. A total of 110 tibial nerve blocks were performed. Location of the injection site was based on a prior ultrasound assessment of the tibial nerve. The...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
ConclusionsUsing the developed nomogram surgeons can estimate the probability of achieving a clinically relevant pain reduction 1 to 2 years after LSF and consequently inform patients on expected outcomes when considering treatment.
Source: European Spine Journal - Category: Orthopaedics Source Type: research
We reported 10 ASA I –II patients admitted for elective primary THA, receiving LIA during (5) and at the end of surgery (5). For the PENG block we used a single injection of 40 ml levobupivacaine 0.25% and dexamethasone 4 mg. For LIA, a mixture of 0.25% levobupivacaine, ketorolac, epinephrine, and morphine was injec ted into periarticular tissues. The pain intensity was evaluated with a numeric rating scale. All patients were fully satisfied and improvement in pain relief, symptoms, and functional activity was remarkable. Intraoperative blood losses ranged 100–600 ml. No intraoperative complicati...
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
ConclusionsAnalgesic effects of continuous QLB were inferior to those of continuous FNB in patients undergoing THA under the current study condition.
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
Condition:   Pain, Postoperative; Anesthesia, Regional Intervention:   Procedure: paravertebral block Sponsors:   Eskisehir Osmangazi University;   Kırıkkale University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Anesthesia | Anesthesiology | Brain | Lidoderm | Neurology | Pain | Skin | Sodium | Study