Hesperetin nanoparticles attenuate anxiogenic-like behavior and cerebral oxidative stress through the upregulation of antioxidant enzyme expression in experimental dementia of Alzheimer's type.

Conclusions: These findings indicated that the administration of Hst and Nano-Hst may be used to treat anxiety -related to AD via an up-regulation of cerebral antioxidant enzyme gene. PMID: 32252616 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research

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We describe a clinical case of a female patient diagnosed with AD with continuous cognitive decline and dementia-related behavioral symptoms. Between 2008 and 2019, the patient was examined half-yearly at the memory clinic of the Medical University of Innsbruck. At each visit, cognitive state and pharmacological treatment were evaluated. In addition, NPs were assessed by using the neuropsychiatric inventory (NPI). In 2018, the patient progressed to severe AD stage and presented with progressive NPs (anxiety, suspected delusions, agitation, aggressive behavior, and suspected pain due to long immobility). Consequently, off-l...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusions: Some comorbidities were present in both the AD and control groups, while others were found in the AD group and not in the control group, and vice versa.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
No abstract available
Source: Psychiatric Genetics - Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research
Conclusions: No clear conclusion can be drawn on the effectiveness of psychoactive cannabinoids in the treatment of psychiatric manifestations, in particular agitation and aggression, in AD. In the future, large randomized controlled trial with adequate designs, without crossover and for longer duration, adapted to cannabinoid pharmacokinetics, is required to establish the real efficacy and safety of these drugs in aggressive and/or agitated patients with AD.
Source: American Journal of Therapeutics - Category: Drugs & Pharmacology Tags: Reviews Source Type: research
Abstract A multidisciplinary advisory group of health professionals involved in dementia care assessed the current evidence base regarding modifiable risk factors (MRFs) for early Alzheimer's disease and mild cognitive impairment. Based on evidence from the published literature and clinical experience, MRFs in four areas were identified where there is evidence to support interventions that may help delay cognitive decline or reduce the risk of developing Alzheimer's disease: medical (eg cardiovascular risk factors), psychosocial (eg depression, anxiety, social isolation), lifestyle (eg lack of physical activity, s...
Source: British Journal of Nursing - Category: Nursing Authors: Tags: Br J Nurs Source Type: research
AbstractDepression, anxiety and apathy are ‘common neuropsychiatric symptoms (NPS) in Alzheimer’s disease (AD). We aimed to find regional gray matter (GM) volume difference of these symptoms, in AD patients compared to AD control, and investigate possible associations of GM atrophy with cognitive covariant. Study subjects were retrieved from the Alzheimer’s Disease Neuroimaging Initiative database. Thirty-five participants are AD control, 27 AD patients with anxiety, 19 with depression and 24 with apathy, ages ≥ 55.1 years. Recruited subjects had an assessment of their clinical and s...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
The foods that contained the highest levels of dementia-fighting antioxidants. → Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia subscribers-only Source Type: blogs
AbstractPurpose of ReviewDementia is a progressive brain disease that affects 5.8 million people in the USA. In 2018, more than 16 million Americans provided unpaid care for persons with dementia (PWD). Most of this care is provided by family members and friends yielding 18.5 billion hours of unpaid care worth $233.9 billion.Novel technological approaches to assist caregivers and improve health and function of PWD are being explored. Models to assess and predict behaviors may provide greater quality of life (QOL) for both PWD and their caregivers. The purpose of this paper is to review current available technologies for be...
Source: Current Geriatrics Reports - Category: Geriatrics Source Type: research
It’s 3 pm on a warm, sunny Saturday. For the past 20 years your mother would dress in her finest clothes and walk to her neighbor’s house for her weekly bridge game. For the past month, however, she has not been interested in playing bridge. Although she sometimes required prompting (as well as reminders to brush her hair), she usually returned from these games cheerful. Her indifference this month is new. Your mother received the diagnosis of mild Alzheimer’s disease last year. Although visibly frustrated at times, especially when she cannot think of the right word or find her pocketbook, she seemed to e...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Behavioral Health Caregiving Healthy Aging Mental Health Source Type: blogs
CONCLUSION: The present study provides preliminary evidence that aMCI patients may benefit from a cognitive intervention program based on re-experiencing recent autobiographical events. However, future studies incorporating a control group will be needed to confirm these preliminary findings. PMID: 32183672 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
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