Antithrombotic Drugs-Pharmacology and Perspectives.

Antithrombotic Drugs-Pharmacology and Perspectives. Adv Exp Med Biol. 2020;1177:101-131 Authors: Li T, Yuan D, Yuan J Abstract Thrombosis, the localized clotting of blood that affects arterial or venous circulation, is one of the leading causes of death worldwide. Arterial thrombosis is commonly initiated by vascular endothelial injury, while venous thrombosis mainly stems from blood stasis. Despite these differences, platelet adhesion, activation and aggregation, and fibrin formation as a result of coagulation constitute the fundamental processes of thrombus formation. Antithrombotic drugs permitted on the clinical currently can dramatically reduce major adverse cardiovascular events; however, they can also increase the bleeding risk. Discovery of antithrombotic drugs that can effectively prevent thrombosis while sparing bleeding side effects remains unmet medical need. In this chapter, we provide an overview on the pathophysiology of thrombosis, followed by introduction of each class of antithrombotic drugs including their pharmacology, clinical applications and limitations. Practical challenges and future perspectives of antithrombotic drugs are discussed in the last part of this chapter. PMID: 32246445 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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Conclusions:Prasugrel and ticagrelor reduced ischemic events and increased bleeding in comparison to clopidogrel. A significant mortality reduction was observed with ticagrelor only. There was no efficacy and safety difference between prasugrel and ticagrelor. PROSPERO ID: CRD42019155648. PMID: 32468837 [PubMed - as supplied by publisher]
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Conditions:   COVID;   Thrombosis;   Bleeding;   Anticoagulation Intervention:   Other: Non-interventional Sponsor:   Imperial College London Recruiting
Source: - Category: Research Source Type: clinical trials
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