Maternal alcoholism and neonatal hypoxia-ischemia: neuroprotection by stilbenoid polyphenols.

This study was inspired by this alarming fact. Its aim was to evaluate the beneficial effects of maternal supplementation with two polyphenols during pregnancy and breastfeeding, on hypoxic-ischemic neonate rat brain damages, sensorimotor and cognitive impairments, in a context of moderate maternal alcoholism. Both stilbenoid polyphenols, trans-resveratrol (RSV - 0.15 mg/kg/day), and its hydroxylated analog, trans-piceatannol (PIC - 0.15 mg/kg/day), were administered in the drinking water, containing or not alcohol (0.5 g/kg/day). In a 7-day post-natal rat model of hypoxia-ischemia (HI), our data showed that moderate maternal alcoholism does not increase brain lesion volumes measured by MRI but leads to higher motor impairments. RSV supplementation could not reverse the deleterious effects of HI coupled with maternal alcoholism. However, PIC supplementation led to a recovery of all sensorimotor and cognitive functions. This neuroprotection was obtained with a dose of PIC corresponding to the consumption of a single passion fruit per day for a pregnant woman. PMID: 32229200 [PubMed - as supplied by publisher]
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research

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(CNN) — If you’re stressed or wanting to enjoy virtual happy hour with friends while pregnant, having a glass of wine every so often may seem like a relaxing plan. But that behavior runs counter to a study published Tuesday in the journal JAMA Network Open. Researchers found drinking or smoking of any level while pregnant — from low to high, and even if you quit early — influenced the brain development of the mothers’ newborns. Negative long-term effects of excessive prenatal alcohol or tobacco exposure (or both), increase the risk for multiple adverse outcomes, researchers observed. Prenatal ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Pregnancy Source Type: news
Conclusions: Identifying these predictive factors will allow the design of more effective fetal alcohol spectrum disorder (FASD) prevention strategies.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
The dangers of alcohol begin at the first sip of the first drink. Although most responsible drinking habits shouldn’t be cause for major concern, everyone who drinks runs the risk of encountering the negative effects of alcohol. The Dietary Guidelines for Americans defines moderate drinking as up to 1 drink per day for women and up to 2 drinks per day for men.  A single drink is considered as: 12 ounces of beer (5% alcohol content) 8 ounces of malt liquor (7% alcohol content) 5 ounces of wine (12% alcohol content) 1.5 ounces of 80-proof (40% alcohol content) distilled spirits or liquor (e.g., gin, rum, vodka, ...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility Alcoholics Anonymous Source Type: blogs
Alcohol consumption during pregnancy is associated with adverse pregnancy outcomes such as preventable alcohol-related developmental disability fetal alcohol syndrome. In Zambia, alcohol use and associated ris...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
Conclusions: The prevalence of CNS anomalies was the highest, followed by musculoskeletal system anomalies. The type of birth defect, gestational age, weight of newborn and twin pregnancy significantly affected outcomes of the newborns with congenital anomalies. Therefore, in order to reduce the prevalence of CMs, the identification and management of risk factors should be the focus of stakeholders.Ethiop. J. Health Dev.2019; 33(3):167-173]Key words: Birth defect, Prevalence, Newborns, Outcomes, South Wollo.
Source: Ethiopian Journal of Health Development - Category: African Health Source Type: research
Prenatal alcohol has long been recognized as having the potential to adversely affect fetal brain development. Alcohol consumption in women of reproductive age and in the first few weeks of an unplanned pregnancy is common. Although some children affected by alcohol exhibit characteristic minor facial anomalies, growth deficiency, and microcephaly (fetal alcohol syndrome), most children affected by alcohol have few or none of these physical features (fetal alcohol spectrum disorders, or FASD). The neurobehavioral abnormalities in FASD can include deficits in cognitive performance, executive functioning, attention, memory, ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Source Type: research
If you’re one of the many homeowners considering using this summer to repaint your house or apartment, you might have been concerned to hear that, according to a just-published study in the journal Occupational &Environmental Medicine, women exposed to common paint chemicals at work are more likely to have a child with autism spectrum disorder. Further, the greater the exposure, the greater the autism risk, the study found. These risks remained even after the researchers adjusted their data to account for other potential autism factors, such as a woman’s smoking history, alcohol habits, and age at the time ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: news
l Fortier Prenatal alcohol exposure is a leading cause of disability, and a major public health concern in Canada. There are well-documented barriers for women and for service providers related to asking about alcohol use in pregnancy. Confidential research is important for learning about alcohol use before, during and after pregnancy, in order to inform fetal alcohol spectrum disorder (FASD) prevention strategies. The Research Advancement through Cohort Cataloguing and Harmonization (ReACH) initiative provides a unique opportunity to leverage the integration of the Canadian pregnancy and birth cohort information regar...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusion: Patients with isolated thalamic atrophy were at a higher risk for not reaching 2-year NEDA-3 and for EDSS increase than patients with no identified brain atrophy. The groups were clinically indistinguishable. A single measurement of thalamic and whole brain atrophy could help identify patients needing most effective therapies from early on. Introduction The quantification of brain atrophy by MRI has become an increasingly important part of evaluating neurodegeneration in MS (1, 2). Atrophy measures can reflect the damage on the central nervous system (CNS) caused by the pathological processes of the dis...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion The key problem with the ND field is the lack of understanding in the events preceding the development of protein-based markers – such as Tau – currently used to diagnose NDs. By this stage, the diseases become more difficult to treat. SncRNAs play an important regulatory role in the maintenance of the homeostatic brain. Therefore, changes in their concentration levels can be indicative of mechanistic changes that could precede protein-based markers. One single sncRNA biomarker is unlikely to differentiate between diseases. However, a combination of sncRNA biomarkers could be illustrative of the me...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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