CO ameliorates cellular senescence and aging by modulating the miR-34a/Sirt1 pathway.
CO ameliorates cellular senescence and aging by modulating the miR-34a/Sirt1 pathway. Free Radic Res. 2020 Mar 31;:1-11 Authors: Park J, Kim J, Chen Y, Song HC, Chen Y, Zheng M, Surh YJ, Kim UH, Park JW, Joe Y, Chung HT Abstract Oxidative stress is recognised as a key factor that can lead to cellular senescence and aging. Carbon monoxide (CO) is produced by haemoxygenase-1 (HO-1), which exerts cytoprotective effects in aging-related diseases, whereas the effect of CO on cellular senescence and aging has not been elucidated. In the current study, we clearly demonstrated that CO delays the process of cellular senescence and aging through regulation of miR-34a and Sirt1 expression. CO reduced H2O2-induced premature senescence in human diploid fibroblast WI-38 cells measured with SA-β-Gal-staining. Furthermore, CO significantly decreased the expression of senescence-associated secretory phenotype (SASP), including TNF-α IL-6, and PAI-1 and increased the transcriptional levels of antioxidant genes, such as HO-1 and NQO1. Moreover, CO apparently enhanced the expression of Sirt1 through down-regulation of miR-34a. Next, to determine whether Sirt1 mediates the inhibitory effect of CO on cellular senescence, we pre-treated WI-38 cells with the Sirt1 inhibitor Ex527 and a miR-34a mimic followed by the administration of H2O2 and evaluated the expression of SASP and antioxidant genes as well as ROS production. According to our results, Sirt1 is crucial for...
Publication date: Available online 30 May 2020Source: The Journal of Chemical ThermodynamicsAuthor(s): Antonin Chapoy, Pezhman Ahmadi, Valdério de Oliveira Cavalcanti Filho, Prashant Jadhawar
Physiological Reports, Volume 8, Issue 11, June 2020.
Publication date: June 2020Source: Annals of Emergency Medicine, Volume 75, Issue 6Author(s): Yifang Xu, Wenchen Li
New J. Chem., 2020, Advance Article DOI: 10.1039/D0NJ01500H, PaperMingming Luo, Zhao Liang, Mingwei Chen, Shaik Gouse Peera, Chao Liu, Hui Yang, Xiaopeng Qi, Juan Liu, Tongxiang Liang CO oxidation on MnC3 and MnC4 has fast kinetics and a low energy barrier. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
CONCLUSION: Lung function abnormalities, psychological impairment and reduced exercise capacity were common in SARS and MERS survivors. Clinicians should anticipate and investigate similar long-term outcomes in COVID-19 survivors. PMID: 32449782 [PubMed - as supplied by publisher]
This study examined the characteristics of particulate matter (PM), nitrogen oxides (NOx), carbon monoxide (CO), and hydrocarbons in diesel locomotive engine exhaust. Emission concentrations were evaluated and compared with the existing regulations. In the case of PM and NOx, emission concentrations increased as engine output increased. High concentrations of CO were detected at engine start and acceleration, while hydrocarbons showed weakly increased concentrations regardless of engine power. Based on fuel consumption and engine power, the emission patterns of PM and gaseous substances observed in this study were slightly...
The recently published Global Lung Function Initiative (GLI) carbon monoxide transfer factor (TLCO) reference equations provide an opportunity to adopt a current, all-age, widely applicable reference set. The aim of this study was to document the effect of changing to GLI from commonly utilised reference equations on the interpretation of TLCO results. 33 863 TLCO results (48% female, 88% Caucasian, n=930 aged
This study was conducted to identify the risk factors associated with acute brain lesions on MRI after acute CO poisoning and to help select patients who need acute-phase brain MRI after acute CO poisoning in the emergency department (ED).
Industrial&Engineering Chemistry ResearchDOI: 10.1021/acs.iecr.0c01623
CONCLUSION: The results of the study suggest that IVIG may be an additional treatment option together with CYC for patients for whom other therapies have failed, but further studies on the exact role of IVIG in the treatment of severe SSc are required. PMID: 32451820 [PubMed - as supplied by publisher]