De Novo Mutations in Mitochondrial DNA of iPSCs Produce Immunogenic Neoepitopes in Humans

Autologous induced pluripotent stem cells (iPSC)-based therapies are considered to be promising in the transplantation field, however their immunological potential is unclear. These therapies require expansion, reprogramming and differentiation of the cells in vitro. Mitochondrial (mt) DNA mutations can arise from those procedures and they have been considered to be involved in the rejection of the cells after transplantation. We therefore hypothesized that single nucleotide polymorphisms (SNPs) in the mtDNA can contribute to autologous and allogeneic graft immunoreactivity and we assessed their immunogenicity in transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (28) Source Type: research