Dysregulation of the Angiopoietin-2/Tie-2 Axis is Associated with Reduced Pulsatility and Increased Arteriovenous Malformation Related Gastrointestinal Bleeding Following Left Ventricular Assist Device Implantation

Recent studies have suggested arteriovenous malformation related gastrointestinal bleeding (AVM-GIB) after left ventricular assist device (LVAD) implantation is associated with reduced arterial pulsatility and right heart failure. Angiopoietin-2 (Ang-2) is elevated among patients on LVAD support, and in concert with abnormal expression of vascular endothelial growth factor (VEGF), binding of Ang-2 to the Tie-2 receptor contributes to abnormal angiogenesis and post-LVAD GIB. The purpose of this study was to evaluate the association between Ang-2, Tie-2, and VEGF with AVM-GIB and its clinical associates.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: J. Newman, Z. Hussain, F. Hussain, M. Poonawalla, E. Bontekoe, H. Ilias Basha, J. Fareed, A. Heroux, M. Liebo, J. Walenga, E. Raichlin Tags: (39) Source Type: research