The Dose-Response Relationship between Gamma-Glutamyl Transferase and Risk of Diabetes Mellitus Using Publicly Available Data: A Longitudinal Study in Japan.

Conclusion: Serum GGT level was a significant predictor of subsequent risk of diabetes mellitus, which increased by 4% for every 1 IU/L increase in GGT when GGT was less than 24 IU/L. PMID: 32215009 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research

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AbstractThe growing burden of non-alcoholic fatty liver disease (NAFLD) parallels the increasing prevalence of obesity in Asia. The overall prevalence of NAFLD in Asia is now estimated to be 29.6% and may have surpassed that in Western populations. NAFLD increases with increasing age and is closely associated with metabolic syndrome. Ethnic differences exist in the prevalence of NAFLD, but the underlying factors are unclear. There were initial concerns about lean NAFLD being associated with more severe liver disease and increased mortality, but subsequent studies suggested otherwise. Only some NAFLD patients progress to de...
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Increasing Upstream Chromatin Long–Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells Angus Li1,2†, Yu Sun1†, Charles Drummer IV1, Yifan Lu1, Daohai Yu3, Yan Zhou4, Xinyuan Li1, Simone J. Pearson1, Candice Johnson1, Catherine Yu5, William Y. Yang1, Kevin Mastascusa1, Xiaohua Jiang1, Jianxin Sun6, Thomas Rogers7, Wenhui Hu1, Hong Wang1 and Xiaofeng Yang1,7* 1Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States 2Department of Biomedical Engineering, Pratt School of Engineering...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
We thank Drs. Tsai and Perng for their interest in and comments on our study.1 They questioned whether diabetes mellitus (DM) was a risk factor of hepatocellular carcinoma (HCC) in Taiwan, where chronic viral hepatitis was prevalent. Indeed, not every study found a significant association between DM and HCC risks. However, the pooled analyses have collectively shown that DM was associated with an increased risk for HCC and the association was independent of alcohol use and viral hepatitis.2,3 The biological mechanism underlying this association remains incompletely understood but most likely involves non-alcoholic fatty li...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Publication date: Available online 21 December 2018Source: Journal of Advanced ResearchAuthor(s): Undurti N. DasAbstractIt has been suggested that hepatitis B virus (HBV)- and hepatitis C virus (HCV)-induced hepatic damage and cirrhosis and associated hypoalbuminemia, non-alcoholic fatty liver disease (NAFLD), and alcoholic fatty liver disease (AFLD) are due to an imbalance between pro-inflammatory and anti-inflammatory bioactive lipids. Increased tumour necrosis factor (TNF)-α production induced by HBV and HCV leads to a polyunsaturated fatty acid (PUFA) deficiency and hypoalbuminemia. Albumin mobilizes PUFAs from t...
Source: Journal of Advanced Research - Category: Research Source Type: research
Publication date: Available online 21 December 2018Source: Journal of Advanced ResearchAuthor(s): Undurti N. DasAbstractIt has been suggested that hepatitis B virus (HBV)- and hepatitis C virus (HCV)-induced hepatic damage and cirrhosis and associated hypoalbuminemia, non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) are due to an imbalance between pro-inflammatory and anti-inflammatory bioactive lipids. Increased tumour necrosis factor (TNF)-α production induced by HBV and HCV leads to a polyunsaturated fatty acid (PUFA) deficiency and hypoalbuminemia. Albumin mobilizes PUFAs from th...
Source: Journal of Advanced Research - Category: Research Source Type: research
Conclusion: In patients with nvHCC, serum ferritin levels are higher in non-diabetics and alcoholics.Liver Cancer 2017;6:307-312
Source: Liver Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsEighty-five percent of the patients with non-B non-C HCC had at least one risk factor for NAFLD. None of the study patients had occult hepatitis B infection. NAFLD is emerging as the major etiological contributing factor for non-B non-C HCC in India.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Conclusion Elevated BMI was an independent risk factor associated with possible LC across the three different etiologies of CLD. As such, weight loss may be beneficial in these patients.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Elevated body mass index is a risk factor associated with possible liver cirrhosis across different etiologies of chronic liver disease. J Formos Med Assoc. 2017 Sep 22;: Authors: Yen YH, Chang KC, Tsai MC, Tseng PL, Lin MT, Wu CK, Lin JT, Hu TH, Wang JH, Chen CH Abstract BACKGROUND/PURPOSE: Metabolic risk factors are associated with liver fibrosis. Whether or not metabolic risk factors affect the severity of liver fibrosis in patients with chronic hepatitis B (CHB), chronic hepatitis C (CHC), or risk factors associated with non-alcoholic fatty liver disease (NAFLD) remains unclear. We aimed...
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
Conclusion: In patients with nvHCC, serum ferritin levels are higher in non-diabetics and alcoholics.Liver Cancer 2017;6:307-312
Source: Liver Cancer - Category: Cancer & Oncology Source Type: research
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