Cancers, Vol. 12, Pages 816: Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively
This study provides evidence showing that a combination of H. pylori infection and capsaicin consumption leads to gastric carcinogenesis mediated through interleukin-6 (IL-6) stimulation with an incidence rate of 50%. The anti-inflammatory role of DFMO highlights the injurious effect of inflammation in gastric cancer development and the need to reduce gastric inflammation for cancer prevention by inhibiting IL-6. Accordingly, preventive measures such as reduced capsaicin consumption, H. pylori clearance, and DFMO treatment may lessen gastric cancer incidence.
Source: Cancers - Category: Cancer & Oncology Authors: Faisal Aziz Mingxia Xin Yunfeng Gao Abhijit Chakroborty Imran Khan Josh Monts Kjersten Monson Ann M. Bode Zigang Dong Tags: Article Source Type: research
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