Dietary intake of choline and phosphatidylcholine and risk of type 2 diabetes in men: The Kuopio Ischaemic Heart Disease Risk Factor Study

AbstractPurposeTo investigate associations of total dietary choline intake and its major dietary form, phosphatidylcholine, with type 2 diabetes risk.MethodsWe included 2332 men aged 42 –60 years at baseline in 1984–1989 from the Kuopio Ischaemic Heart Disease Risk Factor Study in eastern Finland. Dietary intakes were assessed with 4-d food recording at baseline. Type 2 diabetes diagnosis was based on self-administered questionnaires, fasting and 2-h oral glucose tolerance tes t blood glucose measurements, or by record linkage to national health registries. Multivariable-adjusted Cox proportional hazards regression models were used for statistical analysis.ResultsDuring the mean 19.3-year follow-up, 432 men had type 2 diabetes diagnosis. After multivariable adjustments, those in the highest vs. lowest choline intake quartile had 25% (95% CI 2 –43%) lower relative risk(P trend across quartiles  = 0.02) and those in the highest vs. lowest phosphatidylcholine quartile had 41% (95% CI 22–55%) lower relative risk (Ptrend  
Source: European Journal of Nutrition - Category: Nutrition Source Type: research

Related Links:

I have results from my clinic… Three of my diabetic patients went into remission after using hyperbaric oxygen therapy (HBOT). Two patients had type 1 diabetes… and another had type 2 diabetes. All three recovered with oxygen therapy. Most mainstream doctors would scoff at the idea… they “know” there’s no cure for diabetes. And to be treated for it with oxygen seems laughable. If you’re a regular reader, you know more about oxygen therapy than 99% of the general public, including most doctors. But the reason diabetes responds so well to oxygen may surprise you… It al...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Source Type: news
Native Americans and Alaska Natives are up to three times more likely to be diagnosed with type 2 diabetes, according to a statement from the American Heart Association published Thursday by the journal Circulation.
Source: Health News - - Category: Consumer Health News Source Type: news
The present research aimed to analyze the impacts of magnesium and zinc supplements on glycemic control, serum lipids, and biomarkers of oxidative stress and inflammation in patients suffering from coronary he...
Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Research Source Type: research
Abstract BACKGROUND: The aim of the present study was to detect potential gender-specific associations between some common CD36 single nucleotide polymorphisms (SNPs) and the lipid profile, as well as the susceptibility to premature multi-vessel coronary artery heart disease (CHD) in the Han population of Northern China. METHODS: A systematic three-step study process was employed to detect associations between CD36 gene variants and blood lipid profiles, as well as premature multi-vessel CHD in a gender-specific manner. RESULTS: The current study documented the following novel findings: (I) the full popu...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
In conclusion, the growing knowledge of the genetic relationship between T2D and CHD is beginning to provide the promise for improved prevention and treatment of both disorders. PMID: 32437307 [PubMed - as supplied by publisher]
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
By Emma Young We all know that too little sleep is bad for us. Matthew Walker, a UC Berkeley sleep scientist and author of the best-selling Why We Sleep, has gone so far as to declare: “The shorter you sleep, the shorter your life.” However, some researchers fear that our concerns about not getting enough sleep are becoming overblown — and that, ironically, they could be making the problem worse. In this feature, we take a look at evidence that “too little” sleep isn’t always the disaster that it’s held up to be. It’s not always about a lack of sleep You’ll be fami...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Feature Sleep and dreaming Source Type: blogs
In this study, we sought to determine whether diabetes induces dysregulation of miR-532 and if this is associated with accentuated apoptosis. RT-PCR analysis showed a significant increase in miR-532 expression in the right atrial appendage tissue of type 2 diabetic patients undergoing coronary artery bypass graft surgery. This was associated with marked downregulation of its anti-apoptotic target protein apoptosis repressor with caspase recruitment domain (ARC) and increased TUNEL positive cardiomyocytes. Further analysis showed a positive correlation between apoptosis and miR-532 levels. Time-course experiments in a mouse...
Source: Apoptosis - Category: Molecular Biology Source Type: research
Authors: Jafaripour S, Sedighi S, Jokar MH, Aghaei M, Moradzadeh M Abstract Inflammation is a common feature of type 2 diabetes (T2D). Inflammatory cytokines increase in patients with type 2 diabetes, metabolic syndrome, and heart disease. Various types of cells can produce inflammatory cytokines and then release them into the bloodstream, where their complex interactions with target tissues raise a tissue-specific immune response. This review focused on C-reactive protein (CRP), tumor necrosis factor (TNF)-α as an inflammatory cytokine, and adiponectin produced by adipose tissues. Despite the major role of c...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research
NHS ’s first breakdown of underlying health conditions also finds 18% had dementiaCoronavirus – latest updatesSee all our coronavirus coverageOne in four people who havedied in hospital with Covid-19 also had diabetes, the NHS ’s first breakdown of underlying health conditions among the fatalities shows.Of the 22,332 people who died in hospital in England between 31 March and 12 May, 5,873 (26%) suffered from either type 1 or type 2 diabetes, NHS England figures reveal.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak UK news Diabetes Heart disease Dementia NHS Hospitals Health Infectious diseases Medical research Mental health Microbiology Science Society Source Type: news
ConclusionsThe HRQoL of T2DM inpatients with a complication was considerably impaired. Our estimates provide supplementary data for public health and cost-effectiveness modeling, and increase the breadth of knowledge of HRQoL in T2DM.
Source: Quality of Life Research - Category: Health Management Source Type: research
More News: Cardiology | Diabetes | Diabetes Type 2 | Diets | Endocrinology | Finland Health | Heart | Heart Disease | Nutrition | Statistics | Study