Antiviral drug discovery and development for Mayaro Fever - What do we have so far?

Antiviral drug discovery and development for Mayaro Fever - What do we have so far? Mini Rev Med Chem. 2020 Mar 16;: Authors: de Mello MV, Domingos TF, Ferreira D, Ribeiro M, Ribeiro T, Souza A, Rodrigues C Abstract Tropical infectious diseases cause millions of deaths every year in developing countries with about half of the world population living at risk. Mayaro virus (MAYV) is an emerging arbovirus that causes Mayaro fever, which is characterized by fever, headache, diarrhea, arthralgia and rash. These symptoms can be clinically indistinguishable from other arboviruses, such as Dengue, Zika and Chikungunya, which makes the diagnosis and treatment of the disease more difficult. Though, Mayaro virus is a potential candidate to cause large-scale epidemics on the scale of ZIKV and CHIKV. Despite this, there is no licensed vaccine or antiviral for the treatment of Mayaro fever and for most arboviruses, so the design and development of candidates for antiviral drugs are urgently needed. In this context, this mini review aims to provide an overview towards studies of anti-MAYV derivatives and highlight the importance of the discovery and development of promising drug candidates for Mayaro fever. PMID: 32178610 [PubMed - as supplied by publisher]
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research

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Discussion Dengue is an important arboviral infection that affects about 40% of the world population. It is found mainly in topical and subtropical areas of the world mainly in developing countries but it range is spreading including the United States. A review of common arboviruses can be found here. It is a flaviavirus with 4 distinct serotypes named DENV-1 through DENV-4 and is spread by A. aegypti a day biting mosquito. Infection with one serotype confers immunity to that serotype but not the others. It does offer some protection for cross-infection but this only lasts a few months. Incubation period is 3-14 days with ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Adriano Queiroz1, Isabella Fernanda Dantas Pinto2, Maricélia Lima3, Marta Giovanetti1,4, Jaqueline Goes de Jesus1, Joilson Xavier1, Fernanda Khouri Barreto5, Gisele André Baptista Canuto6, Helineide Ramos do Amaral7, Ana Maria Bispo de Filippis4, Denise Lima Mascarenhas8, Melissa Barreto Falcão8, Normeide Pedreira Santos8, Vasco Ariston de Carvalho Azevedo9, Marcos Yukio Yoshinaga2*, Sayuri Miyamoto2 and Luiz Carlos Junior Alcantara1,4,10* 1Laboratório de Patologia Experimental, Instituto Gonçalo Moniz, Salvador, Brazil 2Departamento de Bioquímica, Instituto de Quími...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion and Perspectives Arbovirus infections, such as CHIKV, have been growing worldwide and are becoming a major public health problem, especially in immuno-compromised classes such as children and the elderly. CHIKV is dangerous since it can cause arthritis, fever and other impairments, making it necessary to seek new ways to counter the proliferation of this virus. Knowing the vector’s competence is fundamentally important, including an understanding of the vector virus interaction and the modulation of this interaction. Despite advances in the knowledge of mosquito competence in the transmission of CHIKV, li...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSIONS: Given the similarities in the in itial clinical profiles of these arboviruses, it is important to perform a detailed clinical analysis, laboratory diagnosis, and patient follow-up.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
For most of us, springtime marks the return of life to a dreary landscape, bringing birdsong, trees in bud, and daffodils in bloom. But if you work for the Centers for Disease Control and Prevention (CDC), the coming of spring means the return of nasty diseases spread by ticks and mosquitoes. The killjoys at CDC celebrated the end of winter with a bummer of a paper showing that infections spread by ticks doubled in the United States from 2004 to 2016. (Tick populations have exploded in recent decades, perhaps due to climate change and loss of biodiversity.) Lyme disease The most common infection spread by ticks in the US i...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Source Type: blogs
This study accessed the patients information on demographic characteristics, physical signs and symptoms. Study population This is a cross-sectional and observational study carried out in Brazil during DENV and ZIKV epidemic occurred in 2016. Patients were assisted at the Healthy Unit UPA Coronel Antonino in Campo Grande, MS, Brazil from February to March of 2016. During the study 134 suspected arboviral infection cases were included and submitted to investigation. Patients presenting fever, rash during acute phase of infection (up to the 7th day after disease onset) followed by at least two of the following signals a...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
In this study we explore the potential for autochthonous, but not necessarily sustained, transmission of CHIKV in Canada. We used a stochastic mathematical model parameterized for Ae. albopictus under climatic conditions in the warmest months of the year in locations across Canada. We then combined the climatic suitability for CHIKV transmission potential in the warmest months of the year (condition C4) with climatic suitability indicators for the endemic presence of Ae. albopictus (condition C3) to produce risk maps identifying areas in Canada most suitable for autochthonous CHIKV transmission under recent and projected c...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Public health officials in Brazil suspect that a small yellow fever outbreak in Minas Gerais, a populous landlocked state adjacent to São Paulo state, has infected 110 people and killed 30, according to a Friday report. There is a vaccine for yellow fever, but because the outbreak is taking hold in areas with low vaccination rates, officials are concerned that the disease could continue to spread beyond the state’s borders and cause a larger epidemic, according to the World Health Organization. Yellow fever is spread by the same mosquito that spreads Zika virus, dengue fever and chikungunya.&nbs...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
  Zika continues to be the virus of the day for returning travelers, but there are several other diseases that we need to consider in these patients when they present to us in the emergency department. Chikungunya is epidemic in many of the same countries as Zika and can be even more devastating. And Avian and MERS-CoV is still present in many countries. Unlike patients infected with Zika virus, these patients do require isolation to protect our health care staff from infection. Chikungunya Chikungunya, which means “to walk bent over,” was likely endemic but unrecognized in the United States before the mos...
Source: EPMonthly.com - Category: Emergency Medicine Authors: Tags: Uncategorized Source Type: news
"An MSF assisted cholera treatment center in Mandera, Kenya". June 03, 2016 - Photo credit : @unfpakenBy Siddharth ChatterjeeMandera County, Kenya, Jun 5 2016 (IPS)Mandera’s double whammy, the concurrent outbreaks of cholera and chikungunya, is bringing to the fore the need for accelerated epidemic preparedness and prevention systems. Cholera is an acute diarrhoeal disease that can kill within hours if left untreated.Chikungunya virus is most often spread to people by Aedes aegypti and Aedes albopictus mosquitoes. These are the same mosquitoes that transmit dengue, yellow fever and zika virus. Its symptoms ...
Source: IPS Inter Press Service - Health - Category: Global & Universal Authors: Tags: Africa Development & Aid Education Featured Headlines Health Inequity Population Poverty & SDGs Source Type: news
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