GSE136364 Novel strategies for allogeneic microglia replacements with high efficiency at the brain-wide scale

In this study, we developed three novel strategies of microglia replacement with high replacement efficiency: microglia replacement by bone marrow transplantation (Mr BMT), microglia replacement by peripheral blood (Mr PB) and microglia replacement by microglia transplantation (Mr MT). Mr BMT and Mr PB allow allogeneic microglia-like cells to efficiently replace the resident microglia (up to 98%) at the brain-wide scale. In contrast, Mr MT achieves local replacement of allogeneic microglia in regions of interest. Each approach has its own advantages and application scenarios. We thus believe that the novel microglia replacement strategies are of great implication for future clinical trials for treating microglia-associated CNS disorders.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research