Cancers, Vol. 12, Pages 689: Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC

In this study, we investigated the prevalence of circulating anti-FATE1 antibodies in pediatric and adult patients with adrenocortical tumors using three different methods (immunofluorescence, ELISA and Western blot). Our results show that a pervasive anti-FATE1 immune response is present in those patients. Furthermore, FATE1 expression is a robust prognostic indicator in adult patients with ACC and is associated with increased steroidogenic and decreased immune response gene expression. These data can open perspectives for novel strategies in ACC immunotherapy.

Source: Cancers - March 13, 2020 Category: Cancer & Oncology Authors: Mabrouka Doghman-Bouguerra Pascal Finetti Nelly Durand Ivy Zort éa S. Parise Silviu Sbiera Giulia Cantini Letizia Canu S égolène Hescot Mirna M. O. Figueiredo Heloisa Komechen Iuliu Sbiera Gabriella Nesi Angelo Paci Abir Al Ghuzlan Daniel Birnbaum Eric Tags: Article Source Type: research