Role of Glia in the Regulation of Sleep in Health and Disease.

Role of Glia in the Regulation of Sleep in Health and Disease. Compr Physiol. 2020 Mar 12;10(2):687-712 Authors: Garofalo S, Picard K, Limatola C, Nadjar A, Pascual O, Tremblay MÈ Abstract Sleep is a naturally occurring physiological state that is required to sustain physical and mental health. Traditionally viewed as strictly regulated by top-down control mechanisms, sleep is now known to also originate locally. Glial cells are emerging as important contributors to the regulation of sleep-wake cycles, locally and among dedicated neural circuits. A few pioneering studies revealed that astrocytes and microglia may influence sleep pressure, duration as well as intensity, but the precise involvement of these two glial cells in the regulation of sleep remains to be fully addressed, across contexts of health and disease. In this overview article, we will first summarize the literature pertaining to the role of astrocytes and microglia in the regulation of sleep under normal physiological conditions. Afterward, we will discuss the beneficial and deleterious consequences of glia-mediated neuroinflammation, whether it is acute, or chronic and associated with brain diseases, on the regulation of sleep. Sleep disturbances are a main comorbidity in neurodegenerative diseases, and in several brain diseases that include pain, epilepsy, and cancer. Identifying the relationships between glia-mediated neuroinflammation, sleep-wake rhythm disruption and brain disea...
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research

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I ’ve had a fever, a cough and breathlessness since February, and been in and out of hospital. If it isn’t coronavirus, what is it? BySimon HattenstoneI ’m lying in bed, shivering like crazy. My partner, Diane, is asleep, and I burrow deep into her back. I’m sweating like crazy, too. I’m desperate for the loo, and I run there in my shivery sweats and sweaty shivers. It’s only five minutes since I last went. When I sleep, the same obsessive m oment plays again and again. It’s to do with numbers. I need to get past number nine, but I can’t. The dream lasts for hours. Finally, I...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Medical research Microbiology Science World news Health & wellbeing Boris Johnson Politics Society UK news Conservatives NHS Hospitals Doctors Source Type: news
CONCLUSION: Structural prevention measures in addition to behavioral measures enable a reduction of the cancer risk caused by UV radiation. The aim must be to establish these measures nationwide for the entire population. PMID: 32494842 [PubMed - as supplied by publisher]
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
This study sought to determine the incidence rates of all gynecologic, including peritoneal, malignancies in the U.S. Active Duty population compared to the general US population as reported in the Surveillance, Epidemiology, and End Results Program database. MATERIALS AND METHODS: Gynecologic cancers diagnosed in U.S. Active Duty women aged 20-59 between 2004 and 2013 were retrospectively ascertained. Cancer cases were identified in both the Automated Central Tumor Registry and the Military Health System Data Repository. All cases in Automated Central Tumor Registry plus cases recorded in Military Health System Data R...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
CONCLUSION: Data suggest different roles of opioidergic system and their antagonist in pain control and mood in PTSD. However, further investigations need to be done in order to reveal the role of endogenous opioidergic system and opioidergic antagonist system as a mediator in PTSD patients suffering from acute or chronic pain. PMID: 32492768 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
CONCLUSIONS: MSG administered parenterally to the higher dose to adult rats affects the immunoreactivity of S100β protein in PAG. Phenotypic changes of the studied cells may indicate reactivity of glial cells and increased expression of the studied protein whereas a decrease in their number may result from the increased protein secretion into the extracellular space or cytotoxic death of glial cells. PMID: 32495938 [PubMed - as supplied by publisher]
Source: Folia Histochemica et Cytobiologica - Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
Publication date: Available online 5 June 2020Source: Gynecologic Oncology ReportsAuthor(s): Maryam Kasraeian, Kamran Hessami, Homeira Vafaei, Nasrin Asadi, Leila Foroughinia, Shohreh Roozmeh, Khadije Bazrfashan
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: Available online 4 June 2020Source: Gynecologic Oncology ReportsAuthor(s): María Jesús Rubio, María José Lecumberri, Silvia Varela, Jesús Alarcón, María Eugenia Ortega, Lydia Gaba, Jaime Espinós, Julia Calzas, Pilar Barretina, Isabel Ruiz, Gloria Marquina, Ana Santaballa
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
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Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSIONS: Fusion genes were the most common genetic cause of pediatric PTCs. Fusion gene positive PTCs showed more aggressive behavior than fusion gene negative PTCs. Several novel rearrangements were identified. Fusion genes seem to be a molecular marker number one in pediatric PTC patients. PMID: 32495721 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Conclusions: Pre-injury psychiatric and pre-injury headache/migraine symptoms are risk factors for worse functional and post-concussive outcomes at 3- and 6-months post-mTBI. mTBI patients presenting to acute care should be evaluated for psychiatric and headache/migraine history, with lower thresholds for providing TBI education/resources, surveillance, and follow-up/referrals. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT01565551. Introduction Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality worldwide. In 2013 ~2.8 million TBI cases were recorded annually i...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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