Nanocomposite-siRNA approach for down-regulation of VEGF and its receptor in myeloid leukemia cells.

CONCLUSION: Chitosan nanoparticle siRNA technology can effectively inhibit the expression of VEGF and its receptor in leukemic cells, which led to suppression of their proliferation. Though less efficient than adenoviruses, their non-viral properties suggest that chitosan nanoparticle siRNA complex gene silencing is suitable for further trials.
PMID: 24183807 [PubMed - as supplied by publisher]

Source: International Journal of Biological Macromolecules - October 29, 2013 Category: Biochemistry Authors: Wang L, Zhang WJ, Xiu B, Ding Y, Li P, Ye WD, Zhu Q, Liang AB Tags: Int J Biol Macromol Source Type: research