Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis Via COX-1 (Cyclooxygenase-2).

CONCLUSIONS: In patients with psoriasis, platelets are activated and induce endothelial cell inflammation. Low-dose aspirin improved endothelial cell health in psoriasis via platelet COX-1 inhibition. These data demonstrate a previously unappreciated role of platelets in psoriasis and endothelial cell inflammation, which suggests that aspirin may be effective in improving vascular health in patients with psoriasis. Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT03228017. PMID: 32131611 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32131611?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 4, 2020 Category: Cardiology Authors: Garshick MS, Tawil M, Barrett TJ, Salud-Gnilo CM, Eppler M, Lee A, Scher JU, Neimann AL, Jelic S, Mehta NN, Fisher EA, Krueger JG, Berger JS Tags: Arterioscler Thromb Vasc Biol Source Type: research