Simulation of the Pharmacokinetics of Oseltamivir and Its Active Metabolite in Normal Populations and Patients with Hepatic Cirrhosis Using Physiologically Based Pharmacokinetic Modeling.

In conclusion, the pharmacokinetics of oseltamivir and OC were correctly predicted by PBPK modeling. The model further predicted that the pharmacokinetics of oseltamivir might be altered in liver cirrhosis, depending on the degree of severity. PMID: 32128656 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32128656?dopt=Abstract

Source: AAPS PharmSciTech - March 2, 2020 Category: Drugs & Pharmacology Authors: Chen Y, Ke M, Xu J, Lin C Tags: AAPS PharmSciTech Source Type: research