Clinical effectiveness of high dose versus standard dose of meropenem in ventilator-associated pneumonia caused by multidrug-resistant bacteria: a randomized single-blind clinical trial.

CONCLUSION: Treatment with high dose of meropenem seems to be safe. However, it did not provide significantly higher clinical success rate in comparison with the standard dose, but could be considered as an appropriate empirical treatment in patients with severe infection due to reducing in SOFA and CPIS.
PMID: 32106807 [PubMed - as supplied by publisher]

Source: Infectious Disorders Drug Targets - February 25, 2020 Category: Infectious Diseases Authors: Monajati M, Ala S, Aliyali M, Ghasemian R, Heidari F, Ahanjan M, Moradi S, Sharifpour A, Mojtahedzadeh M, Salehifar E Tags: Infect Disord Drug Targets Source Type: research