Immunological disturbances and neuroimaging findings in Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) comorbid patients.

Immunological disturbances and neuroimaging findings in Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) comorbid patients. Curr Top Med Chem. 2020 Feb 27;: Authors: Kakanakova A, Popov S, Maes M Abstract Mood disorders and Major Depressive Disorder in particular appear to be some of the most common psychiatric disorders with a high rate of comorbidity most frequently of anxiety or substance abuse disorders (alcohol use disorder). In both cases - MDD and AUD a number of immunological disturbances is observed, such as chronic mild inflammation response, increased level of cytokines, hypercortisolaemia, which lead to specific changes in brain neurotransmitter functions. Some of the contemporary brain imaging techniques are functional magnetic resonance imaging (fMRI) and magnetic spectroscopy which are most commonly used to assess the brain metabolism and functional connectivity changes such as altered responses to emotional stimuli in MDD or overactivation of ventromedial prefrontal areas during delayed and underactivation of dorsolateral prefrontal regions during impulsive reward decisions in AUD and dysfunction of gamma-aminobutyric acid (GABA) and/or glutamate neurotransmitter systems, low NAA and myo-Inositol in both MDD and AUD. PMID: 32108009 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research