Insufficient efferocytosis by M2-like macrophages as a possible mechanism of neuropathic pain induced by nerve injury.

In this study, we show that M2-like macrophages accumulate in injured nerves to participate in the clearance of dead or dying cells (i.e., efferocytosis). Because MerTK (a receptor of dead or dying cells) levels on the surface of macrophages are limited, it seems to induce the insufficient of efferocytosis, such that the levels of dead or dying cells cannot be controlled in injured nerves. Given that efferocytosis is pivotal for resolution of inflammation, our data suggest that insufficient efferocytosis is a contributing factor in the development of chronic inflammation in injured nerves. PMID: 32087968 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32087968?dopt=Abstract

Source: Biochemical and Biophysical Research communications - February 18, 2020 Category: Biochemistry Authors: Kobayashi D, Kiguchi N, Saika F, Kishioka S, Matsuzaki S Tags: Biochem Biophys Res Commun Source Type: research