Leptin Affects the Inflammatory Response after Stemi

Publication date: Available online 21 February 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Andrea Demarchi, Iolanda Mazzucchelli, Alberto Somaschini, Stefano Cornara, Veronica Dusi, Alessandro Mandurino Mirizzi, Marta Ruffinazzi, Gabriele Crimi, Marco Ferlini, Massimiliano Gnecchi, Luigi Oltrona Visconti, Stefano De Servi, Gaetano M. De FerrariAbstractLeptin is an adipose tissue-derived hormone primarily involved in the regulation of food intake. Leptine has been shown to have a much broader role than just regulating body weight and appetite in response to food intake: among the others, it has been associated with increased ROS production and inflammation, factors involved in the restoration of an effective myocardial reperfusion after myocardial revascularization. Our study, to our best knowledge, is the first showing a direct relationship between leptin serum levels, inflammatory mediators of the ischemia reperfusion damage and effective myocardial reperfusion in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention. Our findings suggest that leptin serum levels are directly associated with the inflammatory response during an acute myocardial infarction and may have a role in risk stratification in this clinical setting.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research

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Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Research Source Type: research
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Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
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Source: Clinical Biochemistry - Category: Biochemistry Authors: Tags: Clin Biochem Source Type: research
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Source: Trials - Category: Research Source Type: clinical trials
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Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
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