The importance of FDG-PET/CT parameters for the assessment of the immune status in advanced HNSCC
In this study, we examined the relationships between systemic inflammatory parameters and FDG-PET/CT parameters in advanced head and neck squamous cell carcinoma (HNSCC).
Conclusion: Our findings suggested that the SNPs (rs16879870, rs2641256, rs2761591, rs854936) might play a crucial role in prognosis of HNSCC.
The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradiotherapy, but recurrences often occur that are associated with radioresistance. Using human SQD9 laryngeal squamous cell carcinoma cancer cells as a model, we aimed to identify metabolic changes associated with acquired radioresistance. In a top-down approach, matched radiosensitive and radioresistant SQD9 cells were generated and metabolically compared, focusing on glycolysis, oxidative phosphorylation (OXPHOS) and ROS production. The cell cycle, clonogenicity, tumor growth in mice and DNA damage-repair were assessed. Mitoc...
Total laryngectomy (TL) is a definitive surgical approach for larynx cancer, but may not be performed as often in the upfront setting after publication of the VA Larynx Trial in 1991. The aim of the study is to evaluate trends in the upfront utilization of TL as well as patient and oncologic factors associated with TL utilization. We hypothesized that laryngectomy rates would continue to decline with the most recent population data and that racial disparities would narrow.
Verrucous carcinoma is an uncommon, relatively indolent form of laryngeal squamous cell carcinoma. Historically, surgery has been the favored approach, due to concerns of potential anaplastic transformation and secondary metastasis theoretically associated with radiotherapy. To examine national trends in the treatment of verrucous carcinoma of the larynx, we utilized the National Cancer Database (NCDB).
To evaluate patterns of failure, toxicities, and dosimetric impact on dysphagia/aspiration risk structures (DARS) using a direct gross tumor volume (GTV70) to planning target volume expansion (dPTV70) in patients treated for laryngeal squamous cell carcinomas.
In this study, we evaluated the relationship between continued tobacco use (CU) and outcomes in patients undergoing RT, hypothesizing that CU would result in impaired outcomes.
Primary total laryngectomy (TL) is an option for patients with laryngeal cancer who are poor candidates for organ preservation. The purpose of this study was to evaluate complications, functional outcomes, and survival after primary TL for patients with laryngeal cancer.
Definitive radiation remains a treatment option for early stage glottic larynx cancer. Intensity modulated radiation therapy (IMRT) has been the standard treatment for more advanced head and neck cancers, while 3D conformal radiotherapy (3D CRT) has remained standard for early glottic cancers. We used the National Cancer Database (NCDB) to identify predictors of IMRT use and effect on outcome in these patients.
There are few data specifically addressing hypopharynx cancer and thus treatment decisions for it are often extrapolated from laryngeal cancer experiences. We conducted a large population-based analysis of treatment patterns and survival in hypopharynx cancer with the National Cancer Database (NCDB), which to our knowledge has not been done for a non-medicare cohort.
We describe a rare case of cutaneous metastases of laryngeal SCC presenting as multiple eruptive keratoacanthoma-like lesions with concomitant scrofuloderma in an area of previous radiotherapy.