Effect of Proteasome Inhibitors on the AAV-mediated Transduction Efficiency in Retinal Bipolar Cells.

CONCLUSION: Doxorubicin could enhance the AAV transduction efficiency in retinal bipolar cells in vivo. The potential long-term cytotoxicity caused by doxorubicin to retinal neurons could be partially mitigated by dexrazoxane. The coapplication of doxorubicin and dexrazoxane may serve as a potential adjuvant regimen for improving AAV transduction efficiency in retinal bipolar cells. PMID: 32072884 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32072884?dopt=Abstract

Source: Current Gene Therapy - February 9, 2020 Category: Genetics & Stem Cells Authors: Cui S, Ganjawala TH, Abrams GW, Pan ZH Tags: Curr Gene Ther Source Type: research