Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection.

CONCLUSION: N1 showed moderate trypanocidal and promising immunomodulatory activities, and its use in combination with benznidazole and/or anti-arrhythmic drugs as well as the efficacy of its alternative formulations must be investigated in the near future.
PMID: 32074167 [PubMed - as supplied by publisher]

Source: Memorias do Instituto Oswaldo Cruz - February 20, 2020 Category: Infectious Diseases Authors: Cascabulho CM, Meuser-Batista M, Moura KCG, Pinto MDC, Duque TLA, Demarque KC, Guimarães ACR, Manso PPA, Pelajo-Machado M, Oliveira GM, Castro SL, Menna-Barreto RF Tags: Mem Inst Oswaldo Cruz Source Type: research