Systematic Review and Meta-analysis to Estimate the Antibacterial Treatment Effect of Nitrofurantoin for a Non-Inferiority Trial in Uncomplicated Urinary Tract Infection

ConclusionThe corresponding treatment effect estimate for nitrofurantoin was 26.8%, which supports a conservative non-inferiority margin of 12.5% and is consistent with the recently published draft FDA guidance. The findings from this systematic review and meta-analysis inform future antibacterial trials by providing non-inferiority margin justification.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research