Neferine inhibits epidermal growth factor-induced proliferation and migration of retinal pigment epithelial cells through downregulating p38 MAPK and PI3K/AKT signalling.

Conclusion: It can be considered that neferine may be a potential candidate molecule in the treatment of PVR by inhibiting cell proliferation and the migration of EGF-induced RPE cells through the modulation of various transcriptional activities. PMID: 32064963 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32064963?dopt=Abstract

Source: Cutaneous and Ocular Toxicology - February 15, 2020 Category: Toxicology Authors: Ozal SA, Gurlu V, Turkekul K, Guclu H, Erdogan S Tags: Cutan Ocul Toxicol Source Type: research