Synthesis, Characterization and Antitumor Properties of Novel Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes

In this study, two novel benzimidazolium salts consisting propane sulfonate order were integrated in high yields as N-heterocyclic carbene (NHC) precursors.The silver-NHC buildings were set up by responding 1-(2,2-dimethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium and 1-(2,2-diethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium with silver oxide on average state. Gold-NHC edifices were acquired by means of transmetallation of their silver precursors with [AuCl{S(CH3)2}]. The structures of all mixes were completely portrayed by spectroscopic techniques (1H-NMR, 13C{1H} NMR , IR and elemental and further analyzed by DFT/TDDFT strategies. IC50 values and cytotoxic impacts of these four complexes were controlled by the MTS put together examine with respect to three human cancer cell lines neuroblastoma (SHSY5Y), adenocarcinoma (HEP3B), and human fibroblasts (HF).Graphical abstract
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research

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StC. Black The dihydropyranoindole scaffold was identified as a promising target for improving the anti-cancer activity of HDAC inhibitors from the preliminary screening of a library of compounds. A suitable methodology has been developed for the preparation of novel dihydropyranoindoles via the Hemetsberger indole synthesis using azido-phenylacrylates, derived from the reaction of corresponding alkynyl-benzaldehydes with methyl azidoacetate, followed by thermal cyclization in high boiling solvents. Anti-cancer activity of all the newly synthesized compounds was evaluated against the SH-SY5Y and Kelly neuroblastoma ce...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
AbstractPurposePancreatic tumors are rare in children and limited data are available regarding incidence, treatment, and outcomes. We aim to describe patient and tumor characteristics and to report on survival of these diseases.MethodsChildren with pancreatic tumors were queried from the National Cancer Database (2004 –2014). The association between treatment and hazard of death was assessed using Kaplan–Meier method and Cox regression model.ResultsWe identified 109 children with pancreatic tumors; 52% were male and median age at diagnosis was 14  years. Tumors were distributed as follows: pseudopapillary ...
Source: Pediatric Surgery International - Category: Surgery Source Type: research
ConclusionsOverall, our data demonstrate for the first time that low [Na+] promotes cancer progression in vitro, thus suggesting that hyponatremia is not a simple bystander of disease severity in cancer.
Source: Endocrine - Category: Endocrinology Source Type: research
Abstract The in vitro cytotoxic activity on human cancer cell lines of sixteen commercial EOs such as Aloysia triphylla , Boswellia carterii , Boswellia serrata , Cinnamomum zeylanicum , Cistus ladanifer , Citrus × aurantium , Citrus limon , Citrus sinensis , Cymbopogon citratus , Foeniculum vulgare , Illicium verum , Litsea cubeba , Satureja montana , Syzygium aromaticum , Thymus capitatus and Thymus vulgaris was performed using the MTT reduction assay. The screening was carried out on human cancer cells of breast adenocarcinoma (MCF7, T47D and MDA-MDB-231), chronic myelogenous erythroleukaemia (K562) and n...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research
Involvement of PCNP in cell cycle regulation, transcription and apoptosis is demonstrated in this review by integrating online available scientific data about PCNP or related nuclear proteins. A very unique intermediate role of PCNP in cancer immunity is also proposed in this review. AbstractPolypeptide sequences enriched with proline (P), glutamic acid (E), aspartic acid (D) and serine (S)/ threonine (T) (PEST) have been reported to be the most abundant and frequently distributed at the cellular level. There is growing evidence that PEST sequences act as proteolytic recognition signals for degradation of residual proteins...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research
Molecular alterations in malignant disease result in the expression or upregulations of various targets that can be used for imaging and treatment with radiopharmaceuticals. This theranostic principle has acquired greater importance in personalized medicine in recent years, particularly in oncology, where advanced tumors can be treated effectively with low side effects. Since the pioneering use of 131I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177Lu-labeled somatostatin anal...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Supplement Source Type: research
This study indicated that these compounds may represent valuable lead structures for the development of new anticancer agents.Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
Novel Notch signaling inhibitor NSI‑1 suppresses nuclear translocation of the Notch intracellular domain. Int J Mol Med. 2019 Jul 19;: Authors: Shiraishi T, Sakaitani M, Otsuguro S, Maenaka K, Suzuki T, Nakaya T Abstract The Notch receptor serves a fundamental role in the regulation of cell fate determination through intracellular signal transmission. Mutation of the Notch receptor results in abnormal active signaling, leading to the development of diseases involving abnormal cell growth, including malignant tumors. Therefore, the Notch signaling pathway is a useful pharmacological target for the tr...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons Hironori Bando1,2, Youngae Lee1,2, Naoya Sakaguchi1, Ariel Pradipta1, Ryoma Sakamoto1, Shun Tanaka1, Ji Su Ma1,2, Miwa Sasai1,2 and Masahiro Yamamoto1,2* 1Department of Immunoparasitology, Research Institute for Microbial Diseases, Suita, Japan 2Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan Toxoplasma gondii is an important human and animal pathogen that causes life-threatening toxoplasmosis. The host immune system produces interferon-γ (I...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusions sections. Both authors shared in the final refinement of the manuscript. Funding Salary support for WG by National Science Foundation grant 1624615 is gratefully acknowledged. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We gratefully acknowledge very useful comments from Peter Klein on an earlier version of this manuscript, and from the reviewers of this paper, whose comments have resulted in improvements. An earlier version of this...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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