Empirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of Mortality in Patients With Pneumonia

This cohort study compares 30-day mortality among adult patients hospitalized for pneumonia receiving empirical anti –methicillin-resistant Staphylococcus aureus (MRSA) therapy vs standard empirical antibiotic regimens.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research

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Objective: to study features of pulmonary complications in intravenous drug users (IDUs) with and without HIV.Materials and Methods: 149 patients (111 were males, mean age - 34,6±5,2 years)- IDUs diagnosed with pneumonia who were included in the study as they admitted to the hospital. HIV infection was verified in 112 (75%). 105 (70%) patients had viral hepatitis (B, C, B+C), 70 (47%) -tuberculosis.Results: In the presence of HIV infection, especially with severe immunosuppression of CD4+
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
In this study, we investigated the efficacy of antibiotic therapies and the impact of S. aureus alpha-toxin in a model of lethal influenza virus and MRSA coinfection. We demonstrate that antibiotics primarily attenuate alpha-toxin-induced acute lethality, even though both alpha-toxin-dependent and -independent mechanisms significantly contribute to animal mortality after coinfection. Furthermore, we found that the protein synthesis-suppressing antibiotic linezolid has an advantageous therapeutic effect on alpha-toxin-induced lung damage, as measured by protein leak and lactate dehydrogenase (LDH) activity. Importantly, usi...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host Response and Inflammation Source Type: research
Abstract The use of a drug administration plan and therapeutic drug monitoring (TDM) based on pharmacokinetic-pharmacodynamic (PK-PD) analysis is important for the effective use of antimicrobial agents to treat infections. We focused on the use of beta-lactam agents, anti-methicillin-resistant Staphylococcus aureus (MRSA) agents, and an antifungal agent as antimicrobial agents and examined their efficacy in patients under special clinical conditions from the viewpoint of safety and TDM. Our PK-PD analysis of the use of an administration plan to set an optimum serum level for beta-lactam agents or anti-MRSA drugs f...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Conclusion The results of our study demonstrate that robenidine is not suitable as a sole antimicrobial agent for the treatment of Gram-negative pathogen infections due to the lack of activity against the majority of Gram-negative isolates except for A. baumannii and A. calcoaceticus. However, we demonstrated in vitro efficacy against all selected Gram-negative organisms when robenidine was tested in combination with EDTA or PMBN, including against multidrug-resistant strains. Therefore, robenidine may be an appropriate candidate as a component of a combination preparation for the treatment of otitis externa in dogs. This...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
We report a case of concurrent development of active pulmonary tuberculosis and invasive pulmonary aspergillosis (IPA) in a patient who received therapy with infliximab for Crohn’s disease. He has been treated with antitubercular therapy and liposomal amphotericin B for 8 weeks. His clinical course was complicated by paroxysmal atrial fibrillation requiring maintenance therapy with amiodarone, respiratory failure due both to pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamases (ESBL)-producing Klebsiella pneumoniae and pleural effusion requiring chest drainage. ...
Source: IDCases - Category: Infectious Diseases Source Type: research
Conclusion: There is a high reported exposure to antibiotics and awareness of the problem of MDR pathogens. Despite personal worries, most of the participants indicated a reasonable, non-stigmatizing behavior toward carriers of MDR pathogens, and that every individual was responsible to avoid their spread. Introduction The development of antibiotic resistance is a major public health concern in Europe (European Centre for Disease Prevention and Control, 2017) and worldwide (World Health Organization [WHO], 2014). Antibiotic resistances cause longer hospital stays, increased mortality (Ott et al., 2010), and substan...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Authors: Papadopoulos D, Bader I, Gkioxari E, Petta V, Tsaras T, Galanopoulou N, Archontouli MA, Diamantea F, Kastanakis E, Karagianidis N, Filaditaki V Abstract Aspiration pneumonia has a high incidence in hospitalized patients with community-acquired pneumonia and results in high mortality rates. We aimed to evaluate microbiology and assess prognostic factors of aspiration pneumonia in the setting of a tertiary hospital pulmonology department. Community-acquired (CAAP) and healthcare-associated aspiration pneumonia (HCAAP) cases hospitalized over a period of a year were prospectively followed. Demographic, clinic...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
AbstractBackground Methicillin-resistantStaphylococcus aureus (MRSA) is an important cause of pneumonia and clinicians must determine when empiric antimicrobial therapy directed toward MRSA is needed.Objective To evaluate the effect of a pharmacy-driven protocol utilizing the nasal swab MRSA polymerase chain reaction (PCR) test to discontinue vancomycin on duration of vancomycin therapy and clinical outcomes in patients with suspected community-acquired pneumonia (CAP) or healthcare-associated pneumonia (HCAP).Setting A teaching hospital in Huntington, WV, USA.Methods This retrospective study included adult patients who re...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
Vancomycin remains the gold standard of treatment for methicillin-resistant Staphylococcus aureus (MRSA) serious infections; however, the emergence of strains with reduced vancomycin susceptibility warrants the need for alternative therapies. Tigecycline (TGC) is a broad-spectrum protein synthesis inhibiting antibiotic that is active against Gram-positive and Gram-negative organisms, including multidrug-resistant (MDR) bacteria. The FDA approved its use for the treatment of complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Letter to the Editor Source Type: research
ConclusionCaution in utilizing the combination of vancomycin and PTZ is warranted in pediatrics as well. Healthcare professionals should practice increased vigilance if this combination is to be initiated with close monitoring for renal function. Antibiotic therapy de‐escalation should be considered as soon as culture results are available.This article is protected by copyright. All rights reserved.
Source: Pediatrics International - Category: Pediatrics Authors: Tags: Original Article Source Type: research
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