Attenuated baroreflex in a Parkinson's disease animal model coincides with impaired activation of non-C1 neurons

Orthostatic hypotension is one of the most common symptoms observed in Parkinson's disease (PD), a neurodegenerative disease caused by death of dopaminergic neurons in the substantia nigra pars compacta (SNc), and it is associated with denervation of the heart and impairment of the baroreflex. Here, we aimed to investigate if the impaired baroreflex was associated with lower activation of cardiovascular brainstem areas in a 6-hydroxydopamine (6-OHDA) animal model of PD. The PD model was generated with male Wistar rats by injection of 6-OHDA or vehicle into the striatum.
Source: Autonomic Neuroscience: Basic and Clinical - Category: Neuroscience Authors: Source Type: research

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Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases in the world with a harmful impact on the quality of life. Although its clinical diagnosis is based on motor symptoms such as resting tremor, postural instability, slow gait, ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
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Source: Neurology Today - Category: Neurology Tags: In the Pipeline Source Type: research
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Source: Neurology Today - Category: Neurology Tags: Disease Mechanisms Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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