Cross-resistance of isoniazid, para-aminosalicylic acid and pasiniazid against isoniazid-resistant Mycobacterium tuberculosis isolates in China

ConclusionTaken together, these results demonstrate that PAS resistance and mutations in thekatG gene, inhA promoter or oxyR–ahpC intergenic region in INH-resistant M. tuberculosis have little effect on pasiniazid susceptibility.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research

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Publication date: Available online 1 April 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Ayush Lohiya, Rizwan Suliankatchi Abdulkader, Rama Shankar Rath, Olivia Jacob, Palanivel Chinnakali, Akhil Dhanesh Goel, Sumita Agrawal
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 1 April 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Ibrahim Bitar, Medvecky Matej, Amlerova Jana, Papagiannitsis Costas, Hrabak Jaroslav
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 March 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Nilma Hirani, Ameeta Joshi, Siddharth Anand, Abhay Chowdhary, Karthik Ganesan, Meenal Agarwal, Nikhil Phadke
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 10 March 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Divakar Sharma, Sandeep Sharma, Juhi Sharma
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 10 March 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Eddie S. Solo, Chie Nakajima, Trevor Kaile, Precious Bwalya, Grace Mbulo, Yukari Fukushima, Sylvia Chila, Nanthan Kapata, Yogendra Shah, Yasuhiko Suzuki
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 3 March 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Md Mahmudul Islam, Yaoju Tan, H.M. Adnan Hameed, Yang Liu, Chiranjibi Chhotaray, Xiaoyin Cai, Zhiyong Liu, Zhili Lu, Shuai Wang, Xingshan Cai, Biyi Su, Xinjie Li, Shouyong Tan, Jianxiong Liu, Tianyu Zhang
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Abstract Antimicrobial resistance (AMR) is a current major health issue, both for the high rates of resistance observed in bacteria that cause common infections and for the complexity of the consequences of AMR. Pathogens like Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Mycobacterium tuberculosis among others are clear examples of antibiotic-resistant threats. Biosurfactants have recently emerged as a potential new generation of anti-adhesive and anti-biofilm agents; mannosylerythritol lipids (MELs) are biosurfactants produced by a range of fungi. A range of structural variants of MELs ca...
Source: Current Microbiology - Category: Microbiology Authors: Tags: Curr Microbiol Source Type: research
27 February 2020 – Today a consortium of philanthropic, non-profit and private sector organizations launched a collaboration that aims to accelerate the development of novel “pan-TB” drug regimens for the treatment of tuberculosis (TB) that are ready for phase 3 development. The regimens will be designed to have little to no drug resistance and an acceptable safety profile, and be better-tolerated, shorter in duration and simpler to use than existing options. Such regimens are intended to be a central component of efforts to address the current complexities and challenges of TB treatment.The members of th...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Chen Antimicrobial resistance (AMR) has become a global threat to not only public health impacts but also clinical and economic outcomes. During the past decades, there have been many studies focusing on surveillance, mechanisms, and diagnostics of AMR in infectious diseases but the impacts on public health, clinical and economic outcomes due to emergence of these AMRs are rarely studied and reported. This review was aimed to summarize the findings from published studies to report the outcome impacts due to AMR of malaria, tuberculosis and HIV and briefly discuss the implications for application to other infectious dis...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
This study served to evaluate the antimicrobial and resistance-modifying profile of a range of plant-derived flavonoids against the mycobacterial model strains: M. smegmatis, M. aurum, and M. bovis BCG. The minimum inhibitory concentrations (MICs) of the compounds against the mycobacterial strains were determined using both agar dilution and broth dilution assays, while their efflux inhibitory activity was investigated via an ethidium bromide-based fluorometric assay. All compounds were screened for their synergistic effects with ethidium bromide (EtBr) and rifampicin (RIF) against M. smegmatis. Skullcapflavone II (5,2&...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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