Clopidogrel or Prasugrel reduces mortality and lessens cardiovascular damage from acute myocardial infarction in Hypercholesterolemic male rats

Publication date: Available online 13 February 2020Source: Life SciencesAuthor(s): Hala M.F. Mohammad, Samy M. Makary, Hoda Atef, Mohamed El-Sherbiny, Hebatallah H. Atteia, Gehan A. Ibrahim, Abdelaty Shawky Mohamed, Sawsan A. ZaitoneAbstractAimsHypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against isoproterenol-induced acute MI (A-MI) under hypercholesterolemic conditions in rats.Main methodsDietary hypercholesterolemic rats were subjected to acute doses of isoproterenol. Serum lipids, inflammatory markers, aortic endothelin1 and endothelial nitric oxide synthase (eNOS) mRNAs expression and immunexpression of BCL2 were determined.Key findingsHypercholesterolemic rats showed infiltration of inflammatory cells and reduction in aortic wall thickness, deposition of fibrous tissue between cardiac muscle fibers. Protective doses of prasugrel or clopidogrel for 28 days before A-MI increased survival, amended the ECG parameters -including ST segment elevation- and improved the histopathological picture in hypercholesterolemic rats. This was coupled with reductions in platelet aggregation, creatine kinase-MB activity, endothelin 1, systemic inflammation and cardiac lipid peroxidation and increment in aortic eNOS expression. Cl...
Source: Life Sciences - Category: Biology Source Type: research