Minocycline, Focused on mechanisms of resistance, antibacterial activity, and clinical effectiveness; Back to Future

Publication date: Available online 12 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Arezoo Asadi, Milad Abdi, Ebrahim Kouhsari, Pegah Panahi, Mohammad Sholeh, Nourkhoda Sadeghifard, Taghi Amiriani, Alireza Ahmadi, Abbas Maleki, Mehrdad GholamiAbstractThe increase of crisis in multidrug-resistant (MDR) or extensively drug-resistant (XDR) microorganisms leads to appealing therapeutic options. During the last 30 years, minocycline has been a wide-spectrum antimicrobial agent, effective against MDR gram-positive and-negative bacterial infections. Alike other tetracyclines, mechanism of action of minocycline is attaching to the bacterial 30S ribosomal subunit and preventing protein synthesis. This antimicrobial agent has been approved for the treatment of acne vulgaris, some sexually transmitted diseases and rheumatoid arthritis. Although many reports have been performed in this field, there remains limited information regarding the prevalence, mechanism of resistance, and clinical effectiveness of minocycline. Thus, we summarize the currently available data concerning pharmacokinetics and pharmacodynamics, mechanism of action and resistance, antibacterial activity, and clinical effectiveness of minocycline.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research