Medial forebrain bundle DBS differentially modulates dopamine release in the nucleus accumbens in a rodent model of depression.

CONCLUSION: The differential impact of MFB DBS on the induced dopamine response, including different response patterns at given pulse widths, is suggestive of physiological and anatomical divergence in the MFB in the pathological and healthy state. Studying how varying stimulation parameters affect the physiological outcome will promote a better understanding of the biological substrate of the disease and the possible anti-depressant mechanisms at play in clinical MFB DBS.
PMID: 32035070 [PubMed - as supplied by publisher]

Source: Experimental Neurology - February 4, 2020 Category: Neurology Authors: Vajari DA, Ramanathan C, Tong Y, Stieglitz T, Coenen VA, Döbrössy MD Tags: Exp Neurol Source Type: research