Therapeutic potential of PPAR γ natural agonists in liver diseases.

Therapeutic potential of PPARγ natural agonists in liver diseases. J Cell Mol Med. 2020 Feb 07;: Authors: Wu L, Guo C, Wu J Abstract Peroxisome proliferator-activated receptor gamma (PPARγ) is a vital subtype of the PPAR family. The biological functions are complex and diverse. PPARγ plays a significant role in protecting the liver from inflammation, oxidation, fibrosis, fatty liver and tumours. Natural products are a promising pool for drug discovery, and enormous research effort has been invested in exploring the PPARγ-activating potential of natural products. In this manuscript, we will review the research progress of PPARγ agonists from natural products in recent years and probe into the application potential and prospects of PPARγ natural agonists in the therapy of various liver diseases, including inflammation, hepatic fibrosis, non-alcoholic fatty liver and liver cancer. PMID: 32031298 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32031298?dopt=Abstract

Source: J Cell Mol Med - February 6, 2020 Category: Molecular Biology Authors: Wu L, Guo C, Wu J Tags: J Cell Mol Med Source Type: research